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normal human cardiac fibroblasts ventricular nhcfv primary cells  (PromoCell)


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    PromoCell normal human cardiac fibroblasts ventricular nhcfv primary cells
    Bulk RNA-seq of HCM, <t>NHCFV,</t> and iHCF cells. A) Pearson correlation coefficients of transcriptome-wide expression levels in HCM, NHCFV, and iHCF. B) Heatmap of expression levels (log 2 (FPKQ+1) of cardiomyocyte marker genes and cardiac <t>fibroblast</t> marker genes in cell types used in this study.
    Normal Human Cardiac Fibroblasts Ventricular Nhcfv Primary Cells, supplied by PromoCell, used in various techniques. Bioz Stars score: 97/100, based on 207 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/normal human cardiac fibroblasts ventricular nhcfv primary cells/product/PromoCell
    Average 97 stars, based on 207 article reviews
    normal human cardiac fibroblasts ventricular nhcfv primary cells - by Bioz Stars, 2026-05
    97/100 stars

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    1) Product Images from "Dissecting Regulatory Non-Coding Heart Disease GWAS Loci with High-Resolution 3D Chromatin Interactions Reveals Causal Genes with Pathophysiological Relevance to Heart Failure"

    Article Title: Dissecting Regulatory Non-Coding Heart Disease GWAS Loci with High-Resolution 3D Chromatin Interactions Reveals Causal Genes with Pathophysiological Relevance to Heart Failure

    Journal: bioRxiv

    doi: 10.1101/2024.10.08.617295

    Bulk RNA-seq of HCM, NHCFV, and iHCF cells. A) Pearson correlation coefficients of transcriptome-wide expression levels in HCM, NHCFV, and iHCF. B) Heatmap of expression levels (log 2 (FPKQ+1) of cardiomyocyte marker genes and cardiac fibroblast marker genes in cell types used in this study.
    Figure Legend Snippet: Bulk RNA-seq of HCM, NHCFV, and iHCF cells. A) Pearson correlation coefficients of transcriptome-wide expression levels in HCM, NHCFV, and iHCF. B) Heatmap of expression levels (log 2 (FPKQ+1) of cardiomyocyte marker genes and cardiac fibroblast marker genes in cell types used in this study.

    Techniques Used: RNA Sequencing Assay, Expressing, Marker

    Tracing regulatory circuits from GWAS signals to target genes using functional genomics. (A) Graphical summary of analyses annotating GWAS loci with 3D chromatin interaction and open chromatin data to prioritize functional variants and identify target genes that may underlie disease associations. Significant eQTLs further corroborated these SNP-gene relationships. (B) Analysis workflow for integration of genetic, expression, and functional genomic data. We layered significant pairwise interactions (chromatin loops) with SNPs and TSSs filtered for accessible regions and highlighted those in expressed TFs’ footprints and expressed target genes, as well as GTEx eQTLs, to identify putative active and functional SNP-gene pairs. (C) Genome-wide contact maps of high-resolution Hi-C interactions from primary human cardiac myocytes (HCM) and normal human cardiac fibroblasts –ventricular (NHCFV) (D) Number of GWAS SNPs associated with heart disease-related traits, including heart failure.
    Figure Legend Snippet: Tracing regulatory circuits from GWAS signals to target genes using functional genomics. (A) Graphical summary of analyses annotating GWAS loci with 3D chromatin interaction and open chromatin data to prioritize functional variants and identify target genes that may underlie disease associations. Significant eQTLs further corroborated these SNP-gene relationships. (B) Analysis workflow for integration of genetic, expression, and functional genomic data. We layered significant pairwise interactions (chromatin loops) with SNPs and TSSs filtered for accessible regions and highlighted those in expressed TFs’ footprints and expressed target genes, as well as GTEx eQTLs, to identify putative active and functional SNP-gene pairs. (C) Genome-wide contact maps of high-resolution Hi-C interactions from primary human cardiac myocytes (HCM) and normal human cardiac fibroblasts –ventricular (NHCFV) (D) Number of GWAS SNPs associated with heart disease-related traits, including heart failure.

    Techniques Used: Functional Assay, Expressing, Genome Wide, Hi-C

    Prioritization of active and functional heart disease-associated SNP-gene pairs in human cardiac myocytes (HCM) and normal human cardiac fibroblasts – ventricular (NHCFV) combining genetics, epigenetics, and transcriptomics. A) Sankey diagram of the cell type-specific variation observed in heart disease-associated SNPs and gene accessibility after filtering for open chromatin, chromatin interaction, and expression features, as outlined in . B) Quantification of accessible SNPs identified in HCM and NHCFV that are within known transcription factor (TF) footprints of TFs that also have detectable mRNA expression. C) Number and overlap of active and functional SNP-gene pairs and corresponding unique target genes identified by GOTHiC and HICCUPS across HCM and NHCFV cells.
    Figure Legend Snippet: Prioritization of active and functional heart disease-associated SNP-gene pairs in human cardiac myocytes (HCM) and normal human cardiac fibroblasts – ventricular (NHCFV) combining genetics, epigenetics, and transcriptomics. A) Sankey diagram of the cell type-specific variation observed in heart disease-associated SNPs and gene accessibility after filtering for open chromatin, chromatin interaction, and expression features, as outlined in . B) Quantification of accessible SNPs identified in HCM and NHCFV that are within known transcription factor (TF) footprints of TFs that also have detectable mRNA expression. C) Number and overlap of active and functional SNP-gene pairs and corresponding unique target genes identified by GOTHiC and HICCUPS across HCM and NHCFV cells.

    Techniques Used: Functional Assay, Expressing



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    normal human cardiac fibroblasts ventricular nhcfv primary cells  (PromoCell)
    97
    PromoCell normal human cardiac fibroblasts ventricular nhcfv primary cells
    Bulk RNA-seq of HCM, <t>NHCFV,</t> and iHCF cells. A) Pearson correlation coefficients of transcriptome-wide expression levels in HCM, NHCFV, and iHCF. B) Heatmap of expression levels (log 2 (FPKQ+1) of cardiomyocyte marker genes and cardiac <t>fibroblast</t> marker genes in cell types used in this study.
    Normal Human Cardiac Fibroblasts Ventricular Nhcfv Primary Cells, supplied by PromoCell, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/normal human cardiac fibroblasts ventricular nhcfv primary cells/product/PromoCell
    Average 97 stars, based on 1 article reviews
    normal human cardiac fibroblasts ventricular nhcfv primary cells - by Bioz Stars, 2026-05
    97/100 stars
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    Bulk RNA-seq of HCM, NHCFV, and iHCF cells. A) Pearson correlation coefficients of transcriptome-wide expression levels in HCM, NHCFV, and iHCF. B) Heatmap of expression levels (log 2 (FPKQ+1) of cardiomyocyte marker genes and cardiac fibroblast marker genes in cell types used in this study.

    Journal: bioRxiv

    Article Title: Dissecting Regulatory Non-Coding Heart Disease GWAS Loci with High-Resolution 3D Chromatin Interactions Reveals Causal Genes with Pathophysiological Relevance to Heart Failure

    doi: 10.1101/2024.10.08.617295

    Figure Lengend Snippet: Bulk RNA-seq of HCM, NHCFV, and iHCF cells. A) Pearson correlation coefficients of transcriptome-wide expression levels in HCM, NHCFV, and iHCF. B) Heatmap of expression levels (log 2 (FPKQ+1) of cardiomyocyte marker genes and cardiac fibroblast marker genes in cell types used in this study.

    Article Snippet: Specifically, we cultured 50 million primary Human Cardiac Myocytes (HCM) cells as well as Normal Human Cardiac Fibroblasts – Ventricular (NHCFV) primary cells, which are commercially available from PromoCell and Lonza respectively.

    Techniques: RNA Sequencing Assay, Expressing, Marker

    Tracing regulatory circuits from GWAS signals to target genes using functional genomics. (A) Graphical summary of analyses annotating GWAS loci with 3D chromatin interaction and open chromatin data to prioritize functional variants and identify target genes that may underlie disease associations. Significant eQTLs further corroborated these SNP-gene relationships. (B) Analysis workflow for integration of genetic, expression, and functional genomic data. We layered significant pairwise interactions (chromatin loops) with SNPs and TSSs filtered for accessible regions and highlighted those in expressed TFs’ footprints and expressed target genes, as well as GTEx eQTLs, to identify putative active and functional SNP-gene pairs. (C) Genome-wide contact maps of high-resolution Hi-C interactions from primary human cardiac myocytes (HCM) and normal human cardiac fibroblasts –ventricular (NHCFV) (D) Number of GWAS SNPs associated with heart disease-related traits, including heart failure.

    Journal: bioRxiv

    Article Title: Dissecting Regulatory Non-Coding Heart Disease GWAS Loci with High-Resolution 3D Chromatin Interactions Reveals Causal Genes with Pathophysiological Relevance to Heart Failure

    doi: 10.1101/2024.10.08.617295

    Figure Lengend Snippet: Tracing regulatory circuits from GWAS signals to target genes using functional genomics. (A) Graphical summary of analyses annotating GWAS loci with 3D chromatin interaction and open chromatin data to prioritize functional variants and identify target genes that may underlie disease associations. Significant eQTLs further corroborated these SNP-gene relationships. (B) Analysis workflow for integration of genetic, expression, and functional genomic data. We layered significant pairwise interactions (chromatin loops) with SNPs and TSSs filtered for accessible regions and highlighted those in expressed TFs’ footprints and expressed target genes, as well as GTEx eQTLs, to identify putative active and functional SNP-gene pairs. (C) Genome-wide contact maps of high-resolution Hi-C interactions from primary human cardiac myocytes (HCM) and normal human cardiac fibroblasts –ventricular (NHCFV) (D) Number of GWAS SNPs associated with heart disease-related traits, including heart failure.

    Article Snippet: Specifically, we cultured 50 million primary Human Cardiac Myocytes (HCM) cells as well as Normal Human Cardiac Fibroblasts – Ventricular (NHCFV) primary cells, which are commercially available from PromoCell and Lonza respectively.

    Techniques: Functional Assay, Expressing, Genome Wide, Hi-C

    Prioritization of active and functional heart disease-associated SNP-gene pairs in human cardiac myocytes (HCM) and normal human cardiac fibroblasts – ventricular (NHCFV) combining genetics, epigenetics, and transcriptomics. A) Sankey diagram of the cell type-specific variation observed in heart disease-associated SNPs and gene accessibility after filtering for open chromatin, chromatin interaction, and expression features, as outlined in . B) Quantification of accessible SNPs identified in HCM and NHCFV that are within known transcription factor (TF) footprints of TFs that also have detectable mRNA expression. C) Number and overlap of active and functional SNP-gene pairs and corresponding unique target genes identified by GOTHiC and HICCUPS across HCM and NHCFV cells.

    Journal: bioRxiv

    Article Title: Dissecting Regulatory Non-Coding Heart Disease GWAS Loci with High-Resolution 3D Chromatin Interactions Reveals Causal Genes with Pathophysiological Relevance to Heart Failure

    doi: 10.1101/2024.10.08.617295

    Figure Lengend Snippet: Prioritization of active and functional heart disease-associated SNP-gene pairs in human cardiac myocytes (HCM) and normal human cardiac fibroblasts – ventricular (NHCFV) combining genetics, epigenetics, and transcriptomics. A) Sankey diagram of the cell type-specific variation observed in heart disease-associated SNPs and gene accessibility after filtering for open chromatin, chromatin interaction, and expression features, as outlined in . B) Quantification of accessible SNPs identified in HCM and NHCFV that are within known transcription factor (TF) footprints of TFs that also have detectable mRNA expression. C) Number and overlap of active and functional SNP-gene pairs and corresponding unique target genes identified by GOTHiC and HICCUPS across HCM and NHCFV cells.

    Article Snippet: Specifically, we cultured 50 million primary Human Cardiac Myocytes (HCM) cells as well as Normal Human Cardiac Fibroblasts – Ventricular (NHCFV) primary cells, which are commercially available from PromoCell and Lonza respectively.

    Techniques: Functional Assay, Expressing